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Effect of Spleen and Lymph Node Removal on Adenovirus Tumor Growth

Arch Surg. 1966;93(6):971-973. doi:10.1001/archsurg.1966.01330060115013.
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REGIONAL lymph node removal has been an established procedure for the treatment of cancer. Recently this concept has been challenged because of the lymphocytes' important role in the hosts' immune response. Much of the stimulus for questioning lymph node excision has come from the expanding field of organ transplantation immunity. Homografts were shown to release antigens which drained to the regional lymph nodes at which site antibodies were formed.1 Numerous experimental studies indicated that this cell-bound antibody was of prime importance in the rejection of the graft.2 It was of interest, therefore, to investigate the regional lymph nodes' influence on tumor growth.

Tumors were induced in newborn hamsters at the site of injection by adenovirus type 12 and later transplanted to adult hamsters where progressive growth occurred in the majority of the animals.3 Infectious virus was not identified in these tumors, but a specific complement-fixing antigen was


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