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Neuroleptanalgesia for Heart and Major Surgery

Arch Surg. 1967;94(1):102-106. doi:10.1001/archsurg.1967.01330070104021.
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NEUROLEPTANALGESIA is based upon the use of a tranquilizer and a narcotic administered intravenously to produce a state of psychic withdrawal and profound analgesia.1 Several series of tranquilizers and narcotics have been investigated in Europe; those currently available for investigation in the United States, droperidol2 and fentanyl citrate,3 represent the most evolved of these so far.

Droperidol, a butyrophenone, is a potent tranquilizer which produces in the patient a state of calm, disinclination to move, and "disconnection" from the surroundings. It has an α-adrenergic blocking effect, which offers some protection against shock, leads to good peripheral perfusion, and "unmasks" hypovolemia. It also protects against epinephrine-induced arrhythmias, and has an antiemetic effect.

Droperidol may cause hypotension by virtue of its α-adrenergic blocking effect and peripheral vasodilatation, particularly when the drug is administered rapidly and in the presence of hypovolemia. The hypotension is usually transitory in the former case,


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