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Intra-arterial Chemotherapy in Advanced Pelvic Tumors

Bedrettin Gorgun, MD; Dean R. Goplerud, MD; Alvin L. Watne, MD
Arch Surg. 1967;94(2):251-257. doi:10.1001/archsurg.1967.01330080089023.
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SOME FORMS of inoperable pelvic cancers remain localized and distant metastases develop late in their course. Those patients with recurrent carcinoma of the cervix do not usually respond to additional x-ray treatment because of the limitations imposed by the wide x-ray portals necessary and poor tissue resistance after previous radiotherapy. Recurrent carcinoma of the rectum responds poorly to most palliative measures. Infusion chemotherapy has been used in 20 patients with recurrent pelvic cancer. In addition five patients received a second course of infusion chemotherapy.

Patient, Selection, and Technique  The 20 patients undergoing pelvic infusion chemotherapy included 13 patients with epidermoid carcinoma of the cervix, 5 with adenocarcinoma of the rectum, 1 with adenocarcinoma of the uterus, and 1 with epidermoid carcinoma of the vulva (Tables 1 and 2). A second course of infusion chemotherapy was given to five patients, one with adenocarcinoma of the uterus and four with epidermoid carcinomas


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