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Familial Hyperparathyroidism

Lawrence E. Stevens, MD; H. Allan Bloomer, MD; Kenneth B. Castleton, MD
Arch Surg. 1967;94(4):524-531. doi:10.1001/archsurg.1967.01330100088014.
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THE OCCURRENCE of hyperparathyroidism in two or more members of the same family was first reported by Goldman in 1936. Twelve additional families with more than one member having hyperparathyroidism have been identified.1-13 These families are to be distinguished from those that have been reported with tumors of multiple endocrine glands; such families have been excluded from this report.

We have encountered an unreported family in which four of six siblings have developed parathyroid adenomas, confirmed by surgical extirpation. Our experiences with the family form the text of this report. This family appears unlike most of those reported in two respects. Many of the families reported have multiple parathyroid gland involvement, whereas our patients had only single gland adenomas. In addition, each of the adenomas was surrounded by compressed normal or hypoplastic tissue. This contrasts with the glandular hyperplasia described in many of the other families recorded.

The members


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