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Cyanoacrylate Adhesive and Hemostasis

Teruo Matsumoto, MC; Robert M Hardaway III, MC; Charles A. Heisterkamp III, MC; K. C. Pani, MD; Fred Leonard, PhD; Peter M. Margetis, DC
Arch Surg. 1967;94(6):858-860. doi:10.1001/archsurg.1967.01330120112021.
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THERE ARE a number of reports of successful use of methyl-2-cyanoacrylate tissue adhesive for hemostasis of various wounds in the liver, kidney, spleen, and pancreas.1-9 Collins demonstrated the efficacy of hemostasis in large excised wounds of the liver surface using spray gun application of various higher homologous monomers (J. A. Collins and K. C. Pani, unpublished data). In this institute, various cyanoacrylate monomers have been used successfully in experimental surgery of the gastrointestinal tract, blood vessel, lung, kidney, and liver (T. Matsumoto and associates, unpublished data).

The purpose of this paper is to evaluate and compare the efficacy for immediate hemostasis in solid organs of methyl-2-cyanoacrylate and the higher homologous monomers.

Materials and Methods  In 10- to 26-kg healthy mongrel dogs of both sexes 15 livers, 15 kidneys, 9 spleens, and 8 pancreata were operated upon. Methyl, propyl, N-butyl, hexyl, heptyl, isobutyl, and monomer mixture of 95% heptyl and


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