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Multiple Colonic Carcinomata

James H. Pingree, MD; Keith Reemtsma, MD; Robert D. Lewis
Arch Surg. 1967;95(6):937-939. doi:10.1001/archsurg.1967.01330180085014.
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IN 1888, Fenger reported a case of double carcinoma of the colon, one at the splenic flexure and one in the ascending colon.1 Dowden, in 1917, reported a case of a patient who had four malignant lesions of the colon, all within six years.2 Since then numerous reports have appeared in the medical literature of similar cases of multiple colonic carcinomata, either occurring simultaneously or separately over an interval time period.3-9 Cokkinis has said that the only explanation for this capable of general application is individual susceptibility, perhaps hereditary or familial.10 Hurt and Broders noted that of nine patients with multiple primary malignant neoplasms, in whom at least one was situated in the large bowel, 44.4% gave a history of malignant neoplasia in other members of the family.11 The case presented in this paper is representative of all of these facts: a member of a


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