0
ARTICLE |

Digitalis Tolerance During Septic Shock

Richard J. Allgood, MD; Paul A. Ebert, MD
Arch Surg. 1968;96(1):91-94. doi:10.1001/archsurg.1968.01330190093021.
Text Size: A A A
Published online

DIGITALIS preparations are recommended in treatment of shock because cardiac failure has been shown to occur in the late stages.1-3 It has been advocated as a general supportive measure since digitalis is known to improve contractility of the normal as well as the failing heart.4,5 Wiggers6 states that as many as 80% of patients in shock develop myocardial failure. Though the basis for administration of digitalis appears sound, little is known regarding dosage toxicity relationships during shock.7 In the present study the tolerance of the heart to acetyl strophanthidin was determined in the normal state and during endotoxin shock.

Methods  Mongrel dogs (10 to 20 kg) were anesthetized with intravenous pentobarbital (30 mg/kg) and ventilation maintained with a mechanical respirator using room air. Lead II of the electrocardiogram was continuously monitored and periodic segments recorded. An intravenous catheter was placed in a peripheral vein and acetyl

Topics

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
/>
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();