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Experimental and Clinical Use of Adhesive on Parenchymatous Organs

Kazuo Ota, MD; Shyunichi Mori, MD; Katsumi Mizuno, MD; Tsunamasa Inou, MD
Arch Surg. 1968;96(2):231-236. doi:10.1001/archsurg.1968.01330200069012.
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HEMORRHAGE from the cut surface is inevitable in the partial resection of liver, pancreas, kidney and spleen. In partial hepatectomy and in partial pancreatectomy the leak of the bile or the pancreatic juice further complicates the cut surface. If the leak continues persistently after operation, it is detrimental to the peritoneum. The use of needles and sutures for stopping the hemorrhage and the leak of the bile or the pancreatic juice may cause additional hemorrhage and the retardation of operation time. To solve this problem, an adhesive, 98% ethyl cyanoacrylate monomer, was used. We have reported that the replacement of methyl radical by the ethyl in the side chain of cyanoacrylate monomer significantly lessens histotoxicity1,2 and that n-butyl, 2-ethylhexyl and isopropyl monomers have no less histotoxicity than ethyl monomer on histologic examination.3

Experimental Surgery 

Materials and Methods.  —Experimental animals were 12 mongrel dogs. The right lobe of the


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