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Lymphoid Polyps of the Ileum Associated With Gardner's Syndrome

Neil R. Thomford, MD; Norton J. Greenberger, MD
Arch Surg. 1968;96(2):289-291. doi:10.1001/archsurg.1968.01330200127027.
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INITIALLY described by Devic and Bussy in 1912,1 the association of osteomas or exostosis, soft-tissue tumors, and multiple polyposis of the colon was established as a predictable inherited syndrome by Gardner and his associates (1950-1953).2-4 Subsequent reports and reviews, such as the analysis of 84 cases collected by Jones and Cornell in 1966,5 have further defined the major features and natural history of this syndrome.

It has been estimated that 50% of untreated patients who have multiple polyposis of the large intestine will develop adenocarcinoma of that organ by age 30.6 In addition to polyps of the colon and rectum, a small number of patients with Gardner's syndrome have adenomatous polyps of the small intestine.7 The premalignant nature of these lesions and, therefore, the need for their removal is suggested by the finding of adenocarcinoma of the small intestine in an occasional patient with Gardner's


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