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Primary Lymphosarcoma of the Breast

Walter I. Hofman, MD; Max L. Goodman, MD
Arch Surg. 1968;96(3):410-413. doi:10.1001/archsurg.1968.01330210088017.
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THE incidence of breast sarcoma in contrast to all breast malignancies is 0.3% to 2.7%,1-8 and the majority of these tumors are fibrosarcomas, with only 62 patients described as having primary lymphoma of the breast.9-38 Documented reports present controversy as to the relationship of systemic lymphoma to the proper treatment of the lesion.6,9,14,32 Recently, it was our experience to see a patient with lymphosarcoma of the breast, seven months postpartum followed by systemic lymphoma and death five months after diagnosis. Of the reported patients, 28 have died with systemic malignant lymphoma and others have not been followed for a sufficient period to exclude systemic lymphoma. DeCosse et al's32 nine patients with five-year survivals following diagnosis and treatment are complicated by sequent lymphoma manifestations in three instances. Oberman38 described a patient with five-year survival that had recurrent lymphoma four years after treatment and she has been


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