PREVIOUS studies in this laboratory1 have established a parallel relationship between pancreatic arterial inflow and pancreatic secretion in response to secretin stimulation. Other studies2 have shown the protective effect of hypothermia in canine experimental pancreatitis. This investigation was undertaken to examine the relationship between pancreatic secretion and pancreatic blood flow during whole-body hypothermia.
Materials and Methods
Under α-chloralose anesthesia, ten mongrel dogs of either sex, weighing 19 to 29 kg (42 to 64 lb), had an electromagnetic flow probe placed on the ascending aorta through a left thoracotomy. After chest closure, a second flow probe was placed on the pancreaticoduodenal artery through a midline abdominal incision. The major pancreatic duct (Santorini) was cannulated with a polyvinyl catheter, and the minor duct (Wirsung), ligated. A femoral artery was cannulated for continuous pressure recording. Ascending aorta (cardiac output less coronary flow) and pancreaticoduodenal artery flows were recorded at 15-minute intervals