Bacteriological Study of Cyanoacrylate Tissue Adhesives

Teruo Matsumoto, MC, USA; Arthur S. Dobek, PhD; K. C. Pani, MD; John J. Kovaric, MC, USA; Harold F. Hamit, MC, USA
Arch Surg. 1968;97(3):527-530. doi:10.1001/archsurg.1968.01340030187023.
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SEVERAL available reports of microbiological studies of n-alkyl α-cyanoacrylate monomers suggest the possibility that methyl-2-cyanoacrylate may have bacteriostatic and bacteriocidal action by which it is self-sterilizing in vitro.1-3

Page and Borick4 cautioned users to sterilize methyl-2-cyanoacrylate monomer before using it clinically because they recovered bacterial spores in the monomer. However, if the monomer kills or inhibits growth of even vegetative forms of bacteria, this property may be advantageous in selecting this monomer for certain uses.

This article describes the effects of n-butyl, isobutyl, and methyl-2-cyanoacrylate monomers upon the growth of various microorganisms in vitro and in vivo.

Materials and Methods  N-butyl, isobutyl, and methyl cyanoacrylate monomers were tested because our experiments indicate that isobutyl, n-butyl, and combinations of methyl and isobutyl or n-butyl are the best monomers available for current clinical uses. Bacteriological effects of monomers were compared with those of oxytetracycline


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