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Origin of Arterial Prosthesis Lining From Circulating Blood Cells

James R. Mackenzie, MD; Michael Hackett, MB, FRCS; C. Topuzlu, MD; David J. Tibbs, MC, MS, FRCS
Arch Surg. 1968;97(6):879-885. doi:10.1001/archsurg.1968.01340060057005.
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THE TYPE and source of the cells which line arterial prostheses placed in experimental animals has been of interest to us. It has been postulated that the endothelial lining came from the ingrowth of the aortic endothelium1; or from the capillaries in the surrounding tissue penetrating the interstices of the graft2; or from the cells of the circulating blood.3,4 The other types of cells which compose the lining of the intima have been thought to arise from the blood monocyte as well as from ingrowth tissue.3,4 The present study was undertaken to further clarify the source of the cells composing the tissue lining of grafts.

Methods  A knitted, crimped terylene prosthesis, 20 cm long and surrounded by a nylon sheath impervious to cells (but not to the diffusion of fluid and electrolytes), was placed between the divided ends of the abdominal aorta of 15 dogs (Fig


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