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The Treatment of Primary Breast Cancer:  Analysis of Various Therapeutic Modalities

Lindsay G. Getzen, MC, USN; Ervin L. Lobpreis, MC, USN; Charles K. Holloway Jr., MC, USN
Arch Surg. 1969;98(2):131-137. doi:10.1001/archsurg.1969.01340080023002.
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The question of treating breast cancer revolves around the least destructive but still adequate mode of therapy that would either cure or, if this is beyond hope, at least prolong life in comfort.

Various regimens have been advocated in the treatment of what is thought to be curable cancer of the breast.1,2 Several of them, consisting of either radical mastectomy (1) alone, (2) combined with radiation without, and (3) with the addition of oophorectomy, or of (4) various combinations with chemotherapy, were employed at the San Diego Naval Hospital over the period of 15 years (1948 to 1962).3

The purpose of this study is to scrutinize the relative merits of these regimens on the basis of results obtained during the follow-up of 215 out of 236 cases of unilateral carcinoma of the breast in the white woman and to compare them with other reported evidence.4 Evaluation of

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