The role of gastrin in gastrointestinal tract physiology is now being extensively studied. In spite of this, very little is known about how gastrin is eliminated from the body. Gillespie and Grossman,1 using hog antral gastrin, have demonstrated, by perfusing alternately the portal and systemic veins of dogs, that there was no difference in the Heidenhain pouch secretions, suggesting the liver had not inactivated their preparation significantly in one pass. It has been demonstrated that a "gastrin-like" substance may be detected in the urine of some patients with Zollinger-Ellison tumors.2,3 This would incriminate the kidneys as possibly playing a role in the elimination of gastrin from the body. To investigate in a preliminary fashion the role the kidneys play, we have studied the effect of nephrectomy on the gastrin stimulated pyloric ligated, vagotomized rat.
One hundred and twenty four male Sprague Dowley rats weighing between 280 and