0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

Effect of Fluorouracil on Intestinal Anastomoses in the Rat

Leonard I. Goldman, MD; Stephen Lowe, BS; Tahseen Al-Saleem, MD
Arch Surg. 1969;98(3):303-304. doi:10.1001/archsurg.1969.01340090079011.
Text Size: A A A
Published online

Some of the effects of fluorouracil on non-neoplastic tissue have been reported.1,2 Larger doses impair healing of musculotaneous wounds, while smaller doses do not affect these wounds or the repair involved in intraperitoneal adhesion formation.3,4 The intestinal tract is especially sensitive to fluorouracil administration. In mice, this agent slows epithelial mitotic activity and results in mucosal regression. Other species also exhibit intestinal susceptibility. Because of this and the occasional need for intestinal resection in fluorouracil treated patients, its effect on intestinal wound healing was studied.

Methods  Four groups of male Sprague-Dawley rats weighing between 250 to 500 gm were pretreated with saline or varying doses of fluorouracil. Group 1 received saline, while 25 mg/kg of fluorouracil was injected daily in the others. Group 2 received one or two days of treatment; group 3, three days of treatment; while group 4 was treated for four or five days. Weights

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();