The study was undertaken to make long-term observations on the level of cholesterol and phospholipid in the blood and bile of patients with or without cholelithiasis. It was hoped that, by comparison, some variations in these components of the bile and blood might be observed that could possibly explain the occurrence or absence of cholelithiasis.
Material and Method
Four patients were studied on a metabolic unit for periods of from five to eight weeks after cholecystectomy and common duct exploration. Three of these patients had established cholelithiasis, the stones being of the mixed (inflammatory) type, while one had an essentially normal gallbladder and common bile duct.Following recovery after the operation, the patients were moved to the metabolic unit where liver function studies were done and the basal metabolic rate measured. The common duct tube was then occluded and the patients received a formula diet that consisted of the following: