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Article |

Endocrine Function of Pancreatic Homotransplants in Dogs The Effect of Immunosuppressive Therapy

Claude Huguet, MD; Pierre Daloze, MD; Louis Orcel, MD; Karl E. Sussman, MD
Arch Surg. 1969;98(3):375-380. doi:10.1001/archsurg.1969.01340090151030.
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The ability of the transplanted pancreas to restore normal blood glucose levels in the pancreatectomized dog was demonstrated first by Gayet and Guillaumie 40 years ago.1 The first successful pancreatic homotransplants using vascular anastomosis were reported by De Jode and Howard in 1962.2 Within the past few years, several experimental studies have emphasized the technical problems related to pancreatic transplantation, the methods of detecting the onset of rejection and the difficulties of preventing this process with immunosuppressive agents.3-10

The present study has two objectives: first, to evaluate the endocrine function of partial and total duodenopancreatic homotransplants at different postoperative stages, and secondly, to study the efficiency of immunosuppressive therapy on the survival of these homografts.

Methods  Nonrelated mongrel dogs of both sexes were used, weighing 8.5 to 17 kg (19 to 38 lb). The anesthesia employed was pentobarbital sodium, supplemented with phencyclidine hydrochloride. Twenty-nine pancreatic homotransplantations were


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