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Body Fluid Compartment Changes Following Large Volume Hemodilution Comparison With and Without Heart Failure

Arthur DeBoer, MD
Arch Surg. 1969;98(5):602-606. doi:10.1001/archsurg.1969.01340110094009.
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The use of hemodilution for cardiopulmonary bypass has been an accepted technique for several years.1 There still exists considerable variation as to the type and amount of diluent used. Perfusates ranging from 5% dextrose and water to a complicated mathematical formula of mixtures including mannitol, low molecular weight dextran, serum albumin, steroids and antibiotics are used with success in various centers.2-4 Low volume prime is considered as essential by some, and others have shown large volume primes are safe and advantageous.5

Probably because of the variations of the amount and types of perfusate, some of the reported postoperative studies differ from ours. We elected to use lactated Ringer's solution as the diluent of choice, as suggested by Neville et al.6 It soon became obvious that those patients with no history of heart failure responded quite differently from those patients who were in congestive failure. An attempt


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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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