We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Thyroid Allografts Implanted in the Marrow Space of Rabbits A Functional and Morphological Evaluation

Eric W. Fonkalsrud, MD
Arch Surg. 1969;98(6):738-741. doi:10.1001/archsurg.1969.01340120086013.
Text Size: A A A
Published online


Although gland function may be expected to follow endocrine autotransplantation in the majority of instances, unmodified endocrine allografts appear to undergo immunologic rejection within 8 to 14 days without ever giving clear evidence of function. An exception to this course of events has been suggested by Medawar,1 who first demonstrated in rabbits that allografts ectopically implanted into certain "immunologically privileged sites," such as the anterior chamber of the eye or the brain, will frequently survive, presumably because of the scant supply of lymphatics to these areas and resultant modification of the characteristic rejection reaction. Although there are conflicting reports regarding the ability of "privileged sites" to permit prolonged survival and function after allogeneic thyroid implantation1-3; neither of the sites that have been studied is of practical significance for clinical ap plication, and they have served primarily as investigational models.

In the present study the marrow space of rabbit


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.