Skin Allograft Survival in Calves:  Influence of Thymectomy and Extracorporeal Irradiation of Blood

Arjun D. Chanana, MB, FRCSE, FRCS; Eugene P. Cronkite, MD; Darrel D. Joel, DVM, PhD; Lewis M. Schiffer, MD
Arch Surg. 1969;98(6):803-805. doi:10.1001/archsurg.1969.01340120151029.
Text Size: A A A
Published online

The observation of Miller of severe immunological deficiencies in adult, thymectomized, total-body-irradiated mice,1 led to the belief that the thymus played an essential role in reestablishing immune mechanisms in adult life. Miller2 implied that after adult thymectomy the animal becomes incapable of producing new immunologically competent cells. This deficiency results in gradual decrease in the ability of the animal to produce an immune response, provided that the noncommitted immunologically competent cells normally die and disappear in time. Adult thymectomy has been added to the recognized methods of immunosuppresion in animals and in man, in an effort to prolong the survival of allografts. The results of such efforts have been conflicting.3-10

We decided to investigate the influence of extracorporeal irradiation of blood (ECIB) and thymectomy on skin allograft survival in calves and to compare these results to those obtained with ECIB alone.11 It has been shown that


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.