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Metabolism of Pancreatic Amylase and Lipase Infused Intravenously Into Dogs

Robert S. Yacoub, MD; Hubert E. Appert, PhD; John M. Howard, MD
Arch Surg. 1969;99(1):54-58. doi:10.1001/archsurg.1969.01340130056010.
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Pancreatic enzymes flow normally, not only into the duodenum, but also into the blood stream.1-4 The circulating enzymes are apparently excreted, at least in part, in the urine.5,6 Increased levels of amylase and lipase in the blood and urine constitute an important factor in the diagnosis of acute pancreatitis.7-16

Recent study by Appert and associates17 from this laboratory, and by Hiatt and Bonorris18,19 have demonstrated that amylase and lipase, infused intravenously, disappear from the blood without being excreted in the urine in appreciable amounts. The present study was undertaken to confirm and extend the latter observations.

The study has been divided into two phases. The first phase (in vivo) has consisted of monitoring the disappearance of amylase and lipase from the plasma after the intravenous autoinfusion or homoinfusion of pancreatic juice or homogenate into mongrel adult dogs. Since the earlier study involved very large doses


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