An Evaluation of Bile Diversion on Induced Hypercholesterolemia

This presentation will attempt to shed some light on hypercholesterolemia, the mechanism of its development, and its prevention by relatively simple surgical procedures aimed at changing the body's basic physiological responses. These investigations assume clinical importance in light of the fact that hypercholesterolemia is considered an important factor in atherosclerosis, the latter being the number-one cause of death in the United States today. The following is a report of our continued experience with biliary diversion procedures on induced hypercholesterolemia in dogs, and a revaluation of the importance of the distal ileum in the bile salt enterohepatic circulation.

Materials and Methods  Hypercholesterolemia was induced in 40 adult, mongrel dogs by a modification of the procedure described by Scott and his colleagues.¹ This consisted of a standard beef canned dog food mixed with 10 gm of cholesterol, 0.25 gm of thiouracil, and 40 gm of cottonseed oil. Since we employed a