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Enlarging the Lumen of the Carotid Sinus An Experimental Treatment of Systemic Arterial Hypertension

A. Moneim Fadali, MCh; Manuel D. Ramos, MD; John R. Johnson, BS; Vincent L. Gott, MD
Arch Surg. 1969;99(5):624-627. doi:10.1001/archsurg.1969.01340170076017.
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The important role of the carotid sinus pressure receptors in regulating the systemic arterial blood pressure has long been recognized.1-3 These pressure sensors are stretch receptors in the wall of the carotid sinus and they relay their stimulating signal by way of the carotid nerve to the vasomotor center in the hypothalamus. These impulses have an inhibitory effect on the vasomotor center leading to vasodilation and decrease in heart rate, cardiac output, venous return, and blood pressure. The stretch placed on these pressoreceptors depends on the wall stress as determined by Laplace's equation.3 The Laplace equation states that T = PR, where T is circumferential wall tension, P is internal distending pressure, and R is radius. Though strictly applicable only for tubes with infinitely thin walls, it provides a basis for understanding the effect of varying the diameter of an artery on the circumferential wall tension. An increase in


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