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Hyperbaric Oxygenation:  Influence on Coronary Blood Flow and Oxygen Delivery to the Myocardium

Bryn T. Williams, MD, FRCS; Bernard Roding, MD; Peter M. Winters, MD; Worthington G. Schenk Jr., MD
Arch Surg. 1969;99(6):758-763. doi:10.1001/archsurg.1969.01340180082017.
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The application of hyperbaric oxygen therapy to the treatment of myocardial infarction and its use in certain cardiac procedures has been largely on an empirical basis; reports in the literature of direct measurement of coronary artery flows under these conditions have been lacking.

Reports of the efficacy of hyperbaric oxygen in preventing ventricular fibrillation in experimental animals after coronary artery ligation have also varied.1,2

Hahnloser3 and Bergofsky4 have independently demonstrated the vasoconstrictor action of hyperbaric oxygen in many regional circulations, and it has also been shown that inhalation of pure oxygen at normal pressures may produce a fall in coronary blood flow.5,6

This study was, therefore, designed to measure directly the effect of high pressure oxygen on coronary artery blood flow and to gain information concerning the amount of oxygen delivered to the myocardium under these conditions.

Method  Ten young adult mongrel dogs weighing from 16.8

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