We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Enzymatic and Ultrastructural Evaluation of Hepatic Preservation in Primates

Decio M. Rangel, MD; Walter L. Bruckner, MD; John E. Byfield, MD; Gerald E. Adomian; Alex Dinbar, MD; Eric W. Fonkalsrud, MD
Arch Surg. 1970;100(3):284-289. doi:10.1001/archsurg.1970.01340210060015.
Text Size: A A A
Published online


The use of monkeys for hepatic physiologic studies is particularly suitable because of their phylogenetic proximity to man. In addition, the existence of a unique smooth muscle sphincter in the hepatic veins of dogs1,2 has made this species unsuitable for hepatic studies that are to be correlated with man. Neill and associates2 have shown that such hepatic venous sphincters are absent in the livers of monkeys and humans. The primateis, therefore, the laboratory animal most suitable for investigations in the areas of hepatic physiology and endotoxin shock.3,4

A prerequisite to the development of improved techniques for prolonged hepatic preservation for liver allotransplantation in man is a thorough knowledge of the biochemical and electron microscopic changes that occur in hepatic cells in the primate as a result of hepatic ischemia.5-7 Cell-stabilizing drugs appear to be of benefit in protecting the integrity of ischemic cells in other species,711


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.