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A New Fluoroalkyl Cyanoacrylate Surgical Adhesive

Robert A. Nelson, DVM; Eldon H. Banitt, PhD; Donald C. Kvam, PhD; J. Kenneth Harrington; Jerry E. Robertson, PhD; Joseph S. Buelow
Arch Surg. 1970;100(3):295-298. doi:10.1001/archsurg.1970.01340210071017.
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Current methods for wound closure and control of hemorrhage, although used for years, leave much to be desired. This is particularly true in surgery involving highly vascular organs, glandular tissue, blood vessels, or the gastrointestinal tract. A safe and effective tissue adhesive would do much to eliminate the undesirable aspects of conventionally used wound repair methods. Over the past several years considerable interest has been focused on the alkyl-2-cyanoacrylates as possible tissue adhesives. However, these agents have disadvantages, not the least of which is the production of a high degree of tissue irritation at the site of application.1-6

In an attempt to develop improved tissue adhesives, a number of new fluoroalkyl cyanoacrylates were synthesized and evaluated in the laboratories of 3M Company. Of the compounds evaluated, β,β,β-trifluoro-isopropyl α-cyanoacrylate (MBR 4197) showed the best apparent combination of high bond strength and acceptable flexibility, relatively low tissue toxicity, and good handling


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