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Zinc Concentrations Within Healing Wounds:  Significance of Postoperative Zincuria on Availability and Requirements During Tissue Repair

John H. Henzel, MD; Marion S. DeWeese, MD; Edgar L. Lichti, PhD
Arch Surg. 1970;100(4):349-357. doi:10.1001/archsurg.1970.01340220025005.
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Zinc, a micronutrient essential to man, has been demonstrated to have a beneficial effect upon wound healing.1 The historical aspects relating to the relationship which exists between this ion and tissue repair have been summarized elsewhere with the results of our own earlier clinical studies.2 During recent years, investigators have documented that this element is essential for function of a number of clinically important biologic enzymes, and that the activity of certain of these zinc-dependent enzymes is altered during particular states of tissue destruction and repair.3,4 It is of pertinent interest that a relative preponderance of total biologic zinc is concentrated within the skin and cutaneous structures, and that certain patients with problems in wound healing exhibit subnormal biologic zinc levels.2,5 The question as to whether posttraumatic alterations of biologic zinc requirements and availability may be affected by urinary loss of this ion, particularly in relation

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