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ARTICLE |

Correlation of Renal Blood-Flow Indices and Histamine Metabolism After Canine Renal Allografting

Thomas C. Moore, MD; Dennis P. Thompson, MD; Michael Hayes, MD
Arch Surg. 1970;101(1):45-51. doi:10.1001/archsurg.1970.01340250047011.
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An inflammatory reaction forms a prominent part of the biochemical and physiological processes involved in the acute rejection of tissue and organ allografts. Significant increase in the size of the transplanted organ with edema and cellular infiltration is a constant feature of acute rejection. In most instances, this process is reversible through the administration of large amounts of corticosteroids. It is probable that a significant portion of the effect of corticosteroids on the reversal of acute allograft rejection is anti-inflammatory.

Unpublished as well as published evidence has been obtained in recent years by us and our associates,1-10 suggesting an involvement of accelerated intracellular histamine formation and release in acute allograft rejection. An increase in intracellular histamine formation from histidine decarboxylase enzyme activity during allograft rejection has been found both at the site of allograft rejection and in distant immunologically involved lymphoid tissue.7,8 Inhibitors of the histamine-forming enzyme have

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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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