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Donor Selection for Renal Transplantation Based on Genotypic Analysis of HL-A in a Family

Olga Jonasson, MD; Edward A. Lichter, MD; William M. Hamby, MD; Roger D. Smith, MD; Clarence L. Gantt, MD; Lloyd M. Nyhus, MD
Arch Surg. 1970;101(2):219-225. doi:10.1001/archsurg.1970.01340260123020.
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Through studies of the distribution of HL-A antigens in a family and related donor selection on the basis of genotyping, excellent results have been achieved in cases of donor-recipient HL-A identity. Similar good results may be achieved in cases of donor-recipient monoallelic compatibility where the donor's nonshared allele is not associated with a major detectable HL-A antigen. In instances of monoallelic incompatibility where donor's nonshared allele is associated with a single detected HL-A antigen, the individual "strengths" of these antigens can be estimated on the basis of the clinical course of the recipient and studies of renal function and histology.


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