Splenectomy for Hematologic Disorders

Seymour I. Schwartz, MD; Roger P. Bernard, MD; James T. Adams, MD; Arthur W. Bauman, MD
Arch Surg. 1970;101(2):338-347. doi:10.1001/archsurg.1970.01340260242036.
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The results of splenectomy for hematologic disorders in 200 patients have been evaluated. Anticipated good results were achieved in all patients with hereditary spherocytosis and over 80% of patients with idiopathic thrombocytopenic purpura. A hematologic improvement in patients with thrombotic thrombocytopenic purpura, thalassemia, myeloid metaplasia, and malignant hemopathy occurred in a significant percentage of cases. The overall in-hospital mortality was 7% but was totally related to the primary disease process. It was concluded that the results justify broadening the indications for splenectomy in patients with hematologic disorders.


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