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Valvar Regurgitation in Acute Infective Endocarditis: Early Replacement

Louie C. Wilson, MD; Benson R. Wilcox, MD; Winfred L. Sugg, MD; Richard M. Peters, MD
Arch Surg. 1970;101(6):756-759. doi:10.1001/archsurg.1970.01340300112018.
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From June 1966 to December 1969, 11 prosthetic valves were inserted in ten patients at North Carolina Memorial Hospital because of valvular regurgitation complicating active infective endocarditis. Indications for operation included intractable heart failure, resistant infection, and repeated embolization. Operative mortality was 40%. One patient died 2½ years following operation from unrelated causes. The five survivors, 20 months to four vears following operation, are well and leading active lives. The predominant organisms were streptococcus and staphylococcus. Two of three patients with positive blood cultures one day prior to surgery and four of six patients with organisms demonstrated microscopically at operation are alive and free of recurrent infection for as long as 3½ years. This experience demonstrates that valve replacement is possible in the active phase of endocarditis if adequate antibiotic coverage is used and the focus of infection removed.


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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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