The velocity of venous pulse waves induced by distal compression of extremities was measured transcutaneously by a Doppler ultrasound method in anesthetized dogs. Venous pulse wave propagation velocity (VPWPV) averaged 1.3 meters/sec. In response to a hemorrhage as small as 10% of the blood volume, VPWPV increased 31% in the first minute. This change was greater and earlier than changes in pulse rate and arterial blood pressure. Immediately after blood loss, VPWPV increases were transient, but later there tended to be a more sustained rise. In profound shock, VPWPV decreased. We suggest that VPWPV reflects changes due to the constriction of veins. This type of measurement may be applicable as a clinical indicator of the response to bleeding provided certain developmental problems may be solved.