The records, culture material, and autopsy data of 27 patients with Candida septicemia revealed that the overall mortality was 72%, attributed in part to their primary disease as well as to the adverse effects of the Candida sepsis. Twenty-five of the 27 patients received multiple blood transfusions within two weeks of their positive blood cultures. Twenty-five patients had indwelling central venous catheters at the time that their positive Candida blood cultures were drawn. All but one of the entire group received broad-spectrum antibiotics in the two-week period preceding their disseminated candidiasis. These features appeared to be significant predisposing factors and probably account for the increased incidence of Candida septicemia noted in this report.