Morphologic Changes of the Liver Following Small Intestinal Bypass for Obesity

Henry R. Shibata, MD; James R. Mackenzie, MD; Shao-nan Huang, MD
Arch Surg. 1971;103(2):229-237. doi:10.1001/archsurg.1971.01350080145022.
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Ten patients were studied one to seven years following small intestinal bypass for obesity. Liver function tests, normal preoperatively and abnormal early postoperatively, returned to normal 6 to 12 months later. Total serum cholesterol levels decreased by 40% to 50%. Serum protein values stayed within normal limits if the patient was on a high protein diet. Liver biopsies for fatty change preoperatively showed variations from 1% to 75% infiltration. Late postoperative observations in nine patients showed an increase in fatty infiltration in six. In two there was a decrease and in one there was no change. Of these nine patients, in two who developed 80% to 90% infiltration postoperatively, restoration of continuity abolished this histologic evidence of fatty metamorphosis. No evidence of cirrhosis was observed in any patient.


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