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June 1972, Vol 104, No. 6 >
ARTICLE | June 1972

Functional Recovery From Acute Rejection as a Guide to Ultimate Renal Graft Survival

Glen R. Silcott, MD; Benjamin H. Barbour, MD; Robert Mendez, MD; Margot D. Bischel, MD; Thomas V. Berne, MD
Arch Surg. 1972;104(6):791-793. doi:10.1001/archsurg.1972.04180060041010.
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A study of 62 renal allografts was made to determine which characteristics of acute rejection may allow early identification of those grafts with a very low probability of ultimate success. Graft survival was reduced to below 20% and patient survival to below 50% with the fourth acute rejection episode. Of those grafts which were unable to return the serum creatinine value to within 20% of the prerejection level, 93% ultimately failed and 47% of the patients died. These features of acute rejection offered the best guides to the ultimate outcome of the transplant and are useful in determining when to abandon a renal allograft rather than subject the patient to the risks of additional immunosuppression.

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