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Clinical Pharmacology: Basic Principles in Therapeutics

Joseph M. Garfield, MD
Arch Surg. 1972;105(1):132. doi:10.1001/archsurg.1972.04180070128032.
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One of the significant medical achievements of our times is the abundance of pharmacologic agents effective for specific diseases. In contrast to the relatively few effective drugs once available, today's physician is confronted with a staggering array of medications, many with potent actions and equally potent side effects. Proper use of such drugs demands that the physician be familiar with the biochemical, pathophysiologic, and ecologic manifestations of disease; that he understand the absorption, metabolism, elimination, and mechanisms of action of the drugs; and that he recognize the circumstances under which drug interactions and untoward reactions are likely to occur.

Toward these ends, Kenneth L. Melmon and Howard F. Morrelli, clinical pharmacologists at the University of California Medical Center, San Francisco, in collaboration with their colleagues, offer a text on principles and applications of clinical pharmacology in the practice of medicine. Their achievement is impressive: a well-organized, rigorous, "state-of-the-art" presentation of


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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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