Clinical Pharmacology: Basic Principles in Therapeutics

Joseph M. Garfield, MD
Arch Surg. 1972;105(1):132. doi:10.1001/archsurg.1972.04180070128032.
Text Size: A A A
Published online


One of the significant medical achievements of our times is the abundance of pharmacologic agents effective for specific diseases. In contrast to the relatively few effective drugs once available, today's physician is confronted with a staggering array of medications, many with potent actions and equally potent side effects. Proper use of such drugs demands that the physician be familiar with the biochemical, pathophysiologic, and ecologic manifestations of disease; that he understand the absorption, metabolism, elimination, and mechanisms of action of the drugs; and that he recognize the circumstances under which drug interactions and untoward reactions are likely to occur.

Toward these ends, Kenneth L. Melmon and Howard F. Morrelli, clinical pharmacologists at the University of California Medical Center, San Francisco, in collaboration with their colleagues, offer a text on principles and applications of clinical pharmacology in the practice of medicine. Their achievement is impressive: a well-organized, rigorous, "state-of-the-art" presentation of


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.