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Article |

Renal Transplantation Without Oliguric Acute Tubular Necrosis

John E. Woods, MD; Frank J. Leary, MD; James H. DeWeerd, MD
Arch Surg. 1972;105(3):427-430. doi:10.1001/archsurg.1972.04180090032008.
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During a nine-month period, 28 consecutive transplants were performed without a single instance of oliguric acute tubular necrosis. Nineteen kidneys were donated by living relatives, and nine were taken from cadavers, with periods of preservation up to 13 hours. All allografts functioned within 90 minutes, and in no case was dialysis necessary because of acute tubular necrosis. Important factors for early posttransplant function include hydration of donors and recipients with liberal use of diuretics, use of "heart-beating cadavers," removal of the kidney only during active diuresis, a means of preservation in cadaver kidneys, and maintenance of a systemic blood pressure to ensure adequate perfusion of the allograft.


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