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Clindamycin in the Treatment of Soft-Tissue Infections

William Schumer, MD; Ronald Lee Nichols, MD; Burton Miller, MD; Eli T. Samet, MD; Gerald O. McDonald, MD
Arch Surg. 1973;106(4):578-581. doi:10.1001/archsurg.1973.01350160190033.
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Clindamycin phosphate, a parenteral preparation of the antibiotic clindamycin, was used to treat 131 patients with documented bacterial infections. Clindamycin therapy effectively eradicated 81% of the infections. There were no apparent systemic toxic effects. Injections of clindamycin phosphate were satisfactorily tolerated for as long as three weeks. Resistant Staphylococcus aureus developed in 8% of the cases.

Thus, parenterally administered clindamycin phosphate appears to be safe and effective in treating serious surgical infections due to gram-positive organisms and shows promise in treating anaerobic infections.


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