Clinical Evaluation of Carcinoembryonic Antigen Test

William R. Meeker Jr., MD; Rafiah Kashmiri, MS; Larry Hunter; William Clapp; Ward O. Griffen Jr, MD, PhD
Arch Surg. 1973;107(2):266-274. doi:10.1001/archsurg.1973.01350200128027.
Text Size: A A A
Published online

We have measured plasma levels of carcinoembryonic antigen (CEA) in 259 patients with a variety of cancers, 266 patients with noncancerous disease, and 176 healthy subjects. Sixty-six of 73 patients with malignant tumors of the gastrointestinal tract had elevated (> 2.5 ng/ml) CEA levels. There was no correlation between CEA level and extent of disease. Inconsistencies were noted between clinical status and CEA levels during follow-up of seven of 26 patients 3 to 96 months postoperatively. Elevated levels of CEA were detected in 117 of 186 patients with nonentodermally derived tumors, 83 of 183 patients with noncancerous disease, and 19 of 176 healthy individuals. The lack of specificity and sensitivity of the CEA test limit its usefulness as a screening procedure. Our data also suggest that it may have limited value in detecting recurrence.


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.