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Localized Tissue Destruction by High-Intensity Focused Ultrasound

Charles A. Linke, MD; Edwin L. Carstensen, PhD; Leon A. Frizzell, MS; Ahmad Elbadawi, MD; Charlotte W. Fridd
Arch Surg. 1973;107(6):887-891. doi:10.1001/archsurg.1973.01350240053015.
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Rat liver and rabbit liver and kidney were exposed to focused ultrasound of 312 w/sq cm (rat) and 900 w/sq cm (rabbit) by direct application of the ultrasound transducer to the surface of the organ exposed. A discrete, narrow, cylindrical zone of tissue necrosis to a depth of approximately 2 cm could be induced in the tissue exposed to the ultrasound. Lesions thus produced were well tolerated and tended to be resorbed over a period of several weeks without evidence of hemorrhage, infection, or adverse systemic effect. In rabbit liver, a linear zone of necorsis was induced by linear movement of the transducer. Development of the use of local high-intensity ultrasound may broaden the clinical scope of thermal destruction of cancer beyond that accomplished by electrocoagulation or cryosurgery.


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