0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

Pulmonary Anatomic Arteriovenous Shunting Caused by Epinephrine

Shinnosuke Nomoto, MD; James L. Berk, MD; Joan F. Hagen; Rebecca Koo, MA
Arch Surg. 1974;108(2):201-204. doi:10.1001/archsurg.1974.01350260055012.
Text Size: A A A
Published online

Pulmonary anatomic arteriovenous (A-V) shunting was measured with technetium Tc 99m human albumin microspheres in 44 anesthetized dogs. In untreated dogs, after a 15- to 30-minute observation period following the first microsphere injection, no significant changes in heart rate, arterial pressure, cardiac output, or the pH occurred, but there was a small increase in arterial oxygen pressure and a small decrease in arterial carbon dioxide pressure. These were attributed to preanesthetic excitement or reactions to the anesthetic itself. The second microsphere injection showed no significant change in pulmonary shunting.

Infusions of epinephrine hydrochloride at the rate of 2μg/kg/min and 4μg/kg/min showed significant increases in the pulmonary shunting to 320% and 573% of control values, respectively, during the same time intervals. Epinephrine in amounts that can be produced endogenously under conditions of stress may cause the opening of anatomic pulmonary A-V shunts.

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();