Out of 246 machine-preserved human cadaveric kidneys, 83 (34%) had an early posttransplant nonfunction. Early posttransplant function was classified as F (immediate and continuing good function), FAR (immediate good function followed by accelerated rejection), SF (slow initial function), and NF (nonfunction).
Early function class NF was related largely to the duration of hemodialysis prior to transplantation and to the presence and degree of recipient presensitization, as determined by antibody-against-panel (AbAP) assays. Early function class NF kidneys also were more frequent in second than in first transplants. The numbers and specificities of HL-A antigens mismatched and machine perfusion characteristics (flow and pressure) were essentially the same for NF and F kidneys.