The Ineffectiveness of Steroid Therapy in Treating Aspiration of Hydrochloric Acid

Roy L. Chapman Jr., MD; John B. Downs, MD; Jerome H. Modell, MD; C. Ian Hood, MB, ChB
Arch Surg. 1974;108(6):858-861. doi:10.1001/archsurg.1974.01350300090021.
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Following aspiration of 0.1N hydrochloric acid with pH 1.0, 20 mongrel dogs were ventilated mechanically for four hours. Positive end-expiratory pressure of 10 cm H2O was added continuous positive-pressure ventilation (CPPV). In addition to CPPV, ten of the dogs received methylprednisolone (30 mg/kg body weight). The CPPV improved arterial oxygen tension, decreased venous admixture, increased arterial-venous oxygen content difference, and decreased systemic blood pressure. The addition of methyl-prednisolone did not significantly improve oxygenation, survival, or any other variable measured.


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