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Cancer of the Thyroid in Three Generations

Arch Surg. 1974;109(3):458. doi:10.1001/archsurg.1974.01360030110032.
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To the Editor.–I have a very interesting follow-up on a case first reported by Drs. Barker and Brines in "Hyperfunctioning Adenoma of an Ectopic Parathyroid Gland" (Arch Surg 39:205, 1939). The patient's course was uneventful from 1939 to 1947, when she developed a nodular goiter. In February 1947 a thyroidectomy was performed, the pathological report was unknown; in 1964 lymph nodes were present and a neck gland dissection was done. The pathological diagnosis at that time was metastatic papillary adenocarcinoma in the lymph nodes, primary thyroid, chronic thyroiditis, and small benign adenomas of the thyroid. In 1971, slides were obtained from the 1964 lymph node dissection and restained for amyloid and reexamined. At this time, the diagnosis was corrected to medullary carcinoma of the thyroid. At the present time, her health is excellent and she shows no sign of metastasis.

I saw the patient's daughter in 1971; she had


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