Fifteen patients had intussusception associated with malignant neoplasm. In 11 of them, metastatic tumor led the intussusception. With metastatic tumors, symptoms were usually shorter than those encountered with benign disease or with primary malignant neoplasm. The triad of abdominal cramps, nausea with vomiting, and abdominal distention, although not diagnostic, appeared most consistently. A palpable abdominal mass or melena was uncommon. The clinical picture was insidious and often confused by the effects of radiotherapy or chemotherapy. Abdominal roentgenograms and a roentgenographic series of the gastrointestinal tract usually indicated intestinal obstruction. The diagnosis of intussusception was rarely made preoperatively. Despite the generally poor prognosis of patients with metastatic disease, surgical intervention is indicated when intussusception occurs.