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Bilateral Adrenalectomy for Metastatic Breast Carcinoma

Peter W. Brown, MD; Jose J. Terz, MD; Roger King, MD; Walter Lawrence Jr., MD
Arch Surg. 1975;110(1):77-81. doi:10.1001/archsurg.1975.01360070077013.
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Ninety-five patients who underwent bilateral adrenalectomy for metastatic breast carcinoma are reviewed. An objective remission of tumor was observed in 66% of the patients over the age of 45 years with metastasis limited to soft tissue, osseous, or pulmonary system. In those patients below the age of 45, only 19% had remission irrespective of the sites of metastasis.

Thirty-three patients were admitted with no "free interval," with objective remission occurring in 42%. This observation indicates that the "free interval" is not as striking a determinant in selecting adrenalectomy candidates as had been stressed by others.

The serial treatment of adrenalectomy followed by chemotherapy after adrenalectomy failure or relapse was shown to objectively benefit 74% of 72 patients evaluated. Sulfokinase activity in breast cancer tissue was studied in 17 patients. The results were not as definitive as reported by others.


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