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August 1975, Vol 110, No. 8 >
ARTICLE | August 1975

Glucocorticoid and Antibiotic Effect on Experimental Gram-Negative Bacteremic Shock

Mary Pitcairn; James Schuler, MD; Peter R. Erve, PhD; Steven Holtzman, MD; William Schumer, MD
Arch Surg. 1975;110(8):1012-1015. doi:10.1001/archsurg.1975.01360140156030.
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This study was designed to answer the three following questions: (1) Are glucocorticoids as protective in Gram-negative bacteremic shock as they are in endotoxic shock? (2) Is there any difference in efficacy between a bacteriostatic and a bactericidal antibiotic in bacteremic shock? (3) Does the combination of glucocorticoid with antibiotic potentiate the individual protective effects of both? Bacteremia was induced in male Sprague-Dawley rats by a single intravenous injection of viable Escherichia coli. The results showed that dexamethasone sodium phosphate alone afforded significant protection against Gram-negative bacteremic shock up to eight hours after challenge. The choice of a bactericidal vs a bacteriostatic antibiotic did not influence the survival rates in this study. The survival rate was maximal when dexamethasone was used with both ampicillin sodium and gentamicin sulfate.

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