Of 206 patients who underwent 221 consecutive renal homografts, two patients had major urologic complications. One patient had a partial ureteric obstruction requiring surgical intervention and ureterostomy. Another patient had a fistula at the ureteropelvic junction secondary to vigorous diuresis in the presence of acute retention; eventually nephrectomy was required, but the patient survived. In one other instance, urinary extravasation was suspected without substantiation and with uneventful recovery of the patient. The total incidence of major urologic complications was less than 1%, with no related deaths.