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Article |

Studies of the Pain Produced by Mafenide Acetate Preparations in Burns

Howard N. Harrison, PhD; Jerry M. Shuck, MD; Elethea Caldwell, MD
Arch Surg. 1975;110(12):1446-1449. doi:10.1001/archsurg.1975.01360180016003.
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• In a double-blind triple cross-over clinical study, 37 patients were exposed to several formulations of mafenide acetate (Sulfamylon Cream) and their pain responses were recorded and converted to a semiquantitative pain index.

The 11.2% concentration in cream was two to three times more painful than the 5% concentration. Hypertonicity and not the pH level appears to be the cause of the pain produced by the high (11.2%) concentration. The tonicity of the cream carrier and 11.2% mafenide acetate are 1,080 mOsm/kg and 1,100 mOsm/kg, respectively, for a total of 2,180 mOsm/kg.

The carrier cream without glycerol and a 5% concentration of mafenide cream were much less painful than the 11.2% concentration of mafenide. Both afforded a great deal of relief to the patients who received the medications.

(Arch Surg 110:1446-1449, 1975)


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